Viscoelasticity of tau proteins leads to strain rate-dependent breaking of microtubules during axonal stretch injury: Predictions from a mathematical model. In Introduction to EEG- and speech-based emotion recognition (pp. Technological basics of EEG recording and operation of apparatus. Hippocampus mild traumatic brain injury network phase coherence plasticity impairment.Ībhang, P. Altogether, our work demonstrates characteristic hippocampal activity with a scaled network model of spiking neurons and reveals the sensitive balance of plasticity mechanisms in the circuit through one manifestation of mild traumatic injury. We also studied the effects of spike-timing-dependent plasticity impairment, a potential consequence of TBI, in our model and found that impairment decreases broadband power in CA3 and CA1 and reduces phase coherence between these two subregions, yet phase-amplitude coupling in CA1 remains intact. Our model mimics key features of hippocampal activity, including signal frequencies in the theta and gamma bands and phase-amplitude coupling in area CA1. In addition, since plasticity is foundational to the role of the hippocampus in learning and memory as well as necessary for studying adaptation to injury, we implemented spike-timing-dependent plasticity among the synaptic connections. The subregions are represented as an interconnected neuronal network, incorporating well-characterized ex vivo slice electrophysiology into the functional neuron models and well-documented anatomical connections into the network structure. In this work, we developed a computational model of the hippocampus, including the dentate gyrus, CA3, and CA1. Although there are many existing models of individual subregions of the hippocampus, few models attempt to integrate the primary areas into one system. Traumatic brain injury (TBI) and other neurological disorders are commonly associated with cognitive deficits and hippocampal dysfunction.
Proper function of the hippocampus is critical for executing cognitive tasks such as learning and memory.
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